Diagnosis and early management of inflammatory arthritis.

Autoimmune inflammation affects the joints of people with inflammatory arthritis. No definitive cause has been identified, despite extensive research. An environmental trigger in a genetically predisposed individual seems to be the most likely mechanism. About 80-100 adults in 100 000 develop inflammatory arthritis every year. 3 Rheumatoid arthritis is the most common inflammatory arthritis, affecting approximately 500 000 people in the UK. Spondylo-arthropathies, which include psoriatic arthritis, reactive arthritis, and ankylosing spondylitis, are slightly less common. In ankylosing spondylitis inflammation occurs mainly in the spine, but peripheral arthritis can occur. Inflammatory arthritis primarily affects people of working age, and within 10 years of diagnosis around 40% of people with rheumatoid arthritis are unable to work. Systematic reviews of randomised controlled trials show that early treatment can control symptoms, induce remission, minimise irreparable damage, and protect against the mortality and morbidity associated with inflammatory arthritis, especially cardiovascular. Guidelines and quality standards from the UK’s National Institute for Health and Care Excellence recommend early aggressive treatment for rheumatoid arthritis. This approach has been shown to be cost effective, and management principles for rheumatoid arthritis are broadly applicable to all forms of inflammatory arthritis. This clinical update, aimed at non specialists, provides information on the diagnosis and early management of inflammatory arthritis. How do patients with inflammatory arthritis present?